High Quality Content by WIKIPEDIA articles! The thrifty gene hypothesis states that connections between low quality fetal and infant growth followed by diabetes mellitus type 2 and metabolic syndrome caused by poor nutrition during early childhood, produces permanent effects in glucose-insulin metabolism. The hypothesis was proposed by geneticist James V. Nee l in 1962 to resolve a fundamental problem. Diabetes is clearly a very harmful medical condition. Yet it is quite common, and it was already evident to Neel that it likely had a strong genetic basis. The problem is to understand how disease with a likely genetic component and with such negative effects may have been favoured by the process of natural selection. Neel suggested the resolution to this problem is that genes which predispose to diabetes (called 'thrifty genes') were historically advantageous, but they became detrimental in the modern world. In his words they were "rendered detrimental by 'progress'". Neel's primary...

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