In the winter of 1664-65, a bitter cold descended on London in the days before Christmas. Above the city, an unusually bright comet traced an arc in the sky, exciting much comment and portending "horrible windes and tempests." And in the remote, squalid precinct of St. Giles-in-the-Fields outside the city wall, Goodwoman Phillips was pronounced dead of the plague. Her house was locked up and the phrase "Lord Have Mercy On Us" was painted on the door in red. By the following Christmas, the pathogen that had felled Goodwoman Phillips would go on to kill nearly 100,000 people living in and around London -- almost a third of those who did not flee. This epidemic had a devastating effect on the city's economy and social fabric, as well as on those who lived through it. Yet somehow the city continued to function and the activities of daily life went on. In The Great Plague, historian A. Lloyd Moote and microbiologist Dorothy C. Moote provide an engrossing and deeply informed...

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