Book DescriptionThis is the first book on diabetes mellitus to incorporate recent molecular and cellular findings with clinical and therapeutic aspects of the disease. The book provides physicians with a thorough understanding of the pathophysiology of diabetes and the scientific rationale for new therapies such as immunosuppression, pancreatic transplantation, engineering the pancreatic -cell, gene therapy, and thiazolidinediones.In 10 sections and 99 chapters, this text covers the spectrum of fundamental and clinical issues. Within each section, chapters progress from basic mechanisms to physiology to therapeutics. Coverage includes critical updates on such topics as new insulin-sensitizing drugs; prevention of type I and type II diabetes; genetics of diabetes; insulin gene regulation; electrophysiology of the pancreatic -cell; the role of IRS-1 during insulin signaling; animal models of autoimmune diabetes mellitus; principles of glucose monitoring; effects of aging...

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