Per-Ingvar Branemark introduced the concept of osseointegrated dental implants and raised the bar for management of dental and orofacial deficits. As a result, long-termclinical outcomes from the technique's scrupulously applied surgical and prosthodontic protocols ushered in a new and exciting dental treatment era, particularly for partially and completely edentulous patients. Subsequent routine dental use of osseointegration resulted from a long research voyage in a vessel made seaworthy by the synergistic efforts of numerous clinical scientists. The loosening of implants from bone tissues has been a cause of problems in reconstructive surgery and joint replacement. The thought for decades has been that the layer of fibrous tissue that develops around the implant diminishes the integrity and mechanical stability of the implant/bone interface. In this brief review article we will attempt to highlight key developments in the research and application of...

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