Cancer is a class of diseases in which a group of cells display uncontrolled growth, invasion, and sometimes metastasis.. Prostate cancer is a form of cancer that develops in the prostate, a gland in the male reproductive system. Most prostate cancers are slow growing. However, there are cases of aggressive prostate cancers. The cancer cells may metastasize from the prostate to other parts of the body, particularly the bones and lymph nodes. Loss of PTEN and concomitant activation of AKT could act in partnership with the TMPRSS2-ERG fusion protein to promote progression to prostate cancer through downstream pathways that increase the selective advantage of pre malignant prostatic intraepithelial neoplasia cells.

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