The aims of this study are modification of locally available denture adhesives material by addition of additives (thymol, sodium fluoride and chlorhexidene) in a concentration of 2% with evaluation of some physical, chemical and biological properties of these materials using Fittydent, Bonyplus and Calcident as comparison groups. These measurements include: pH, density,viscosity, toxicity, antimicrobial effects ,infrared and ultraviolet spectra of all denture adhesive materials. The retentive ability of these materials are also measured and correlated with their viscosity. The results of this study revealed that all the materials tested have nearly a neutral pH. Bonyplus, CMC with thymol, CMC with chlorhexidine and (CMC with thymol, sodium fluoride and chlorhexidene) showed a significant antimicrobial effect. The spectrophotometric result indicated that the modified materials have similar structures to the commercial adhesives.

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