Background and aims. CAD/CAM systems facilitate the use of zirconia substructure materials for all-ceramic copings. This in vitro study investigated the marginal and internal fit of zirconia copings made with CAD/CAM system and slip-casting method. Materials and methods. Sixteen CAD/CAM made zirconia copings and 16 slip-cast made zirconia copings were fabricated and cemented with glass-ionomer cement to their respective master abutment models, and thickness of the cement layer was measured at specific measuring points with stereomicroscope. Results. In the left and right wall, the mean axial internal gap was greater in group one than group two(P =0.007),(P = 0.465). The occlusal internal gap was greater in group one than group two(P =0.423). The mean marginal gap also was greater in group one than group two(P = 0.863). The differences in marginal fit between these two methods were not statistically significant, except for left axial internal gap that was significantly greater in the...

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