In the present experiment, therapeutic efficacy of different intrauterine therapies like normal saline, colostrum and non pathogenic E. coli medication were evaluated and various haematological parameters, predominant bacterial count and quantification of acute phase proteins (CRP, Hp and SAA) were assessed during pre and post treatment period concurrently in cyclic non breeding cows.Basing on the result it can be concluded that the mode of the treatment with non conventional drugs, might act as an alternative choice in treating repeat breeders against traditional antibiotic therapy.

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