Clefts in the orofacial region is one of the most common craniofacial anomaly in man. To understand and treat the condition, deciphering and manipulating the biological information is a must. Tools for the diagnosis and characterization of genetic causes of these disorders are now available because of organized and directed efforts in human genome mapping, advancing frontiers in molecular genetics, molecular diagnostic instrumentation and an explosion in bioinformatics in cell, molecular and developmental biology.This book highlights the genetic influence on craniofacial morphogenesis and also the genetic basis of orofacial clefts and the commonly associated syndromes.

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