A normal cell usually contains a single nucleus with a definitive relationship with the volume of the cytoplasm, but in some situations, cells might contain more than one nucleus sharing a common cytoplasm. The exceptions are skeletal muscle cells, cells of placenta, and bone cells which may contain more than one nucleus, a regular physiological character of these cells; any other cells exhibiting more than one nucleus or an abnormally large sized nucleus are termed as "giant cells”. Giant cells are significantly found in some conditions such as reactive lesions, chronic inflammatory lesions and inflammatory granulomatous lesions. These conditions along with several other entities which contain giant cells as a predominant finding are called "Giant cell lesions”.

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