Stromal myofibroblasts are key cells for the connective tissue remodeling which takes place during wound healing and fibrosis development. Myofibroblasts are not only capable of remodeling connective tissue but also interact with epithelial cells and other connective tissue cells and may thus control such phenomena as tumor invasion and angiogenesis. It has the potential to facilitate progression of neoplastic epithelial lesions that could contribute to their biological behavior. The present review attempts to provide an insight to the role of stromal myofibroblasts in pathogenesis and aggressive behaviour of Squamous cell carcinoma, ameloblastoma and odontogenic keratocyst.

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