Pica is a syndrome of unusual habitat in animals chewing of non food items(depraved appetites). lack of feed or mineral deficiency are predisposing factor to pica, most of Clostridial diseases results of Pica such as " Botulism". Botulism is a diseases affect all types of animal species, it cause by Clostridium botulinum, the disease found world wide and become a problematic concern in late century due to losses in the livestock. The disease affect human, deaths been reported annually by Clostridium botulinum strains. Use of vaccination will be a great of value in controlling the disease and food supplements with minerals lower the factor leads to pica.

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