By the time Europeans arrived in the Americas, they possessed a long list of medicinal plants. They also began looking for new plants to use in medicine. The "Badinus" was the first manuscript to bring New World botanical medicine back to Europe in the 1550s. It was based on the work of an Aztec physician. However, Flannery pointed out, the "Badinus" disappeared, moving from one library to another, until it surfaced in the Vatican in 1929, so it had no effect on the way botanical medicines were used in Europe.

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