Protein folding is a process by which a protein structure assumes its functional shape of conformation. It has been the subject of research since the publication of the first software tool for protein structure prediction. This book approaches the issue by introducing an ab initio model which attempts to simulate as closely as possible, the folding process as it takes place in vivo, and then construct a mechanistic model on the basis of the predictions made.In the opening chapters, the contributors discuss the early stage intermediate and late stage intermediate models, followed by a discussion of structural information that affects the interpretation of the folding process. The second half covers a variety of topics including ligand binding site recognition, the "fuzzy oil drop" model and its use in simulation of the polypeptide chain, and misfolded proteins. The conclusion reviews a number of other ab initio methods for protein structure predictions and some concluding remarks. ...

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