High Quality Content by WIKIPEDIA articles! Virtually all the symptoms and signs of Grave's disease result from the direct and indirect effects of hyperthyroidism, with exceptions being Graves' ophthalmopathy, goitre and pretibial myxedema (which are caused by the autoimmune processes of Graves' disease). These clinical manifestations are dramatic and involve virtually every system in the body. The mechanisms that mediate these effects are not well-understood. The severity of the symptoms and signs of hyperthyroidism is related to the duration of the disease, the magnitude of the thyroid hormone excess, and the patient's age. There is also significant variability in the individual response to hyperthyroidism and individual sensitivity to thyroid hormone fluctuations generally. On top of that, Graves' disease patients can undergo periods of hypothyroidism (for further information, see symptoms of hypothyroidism): finding the right dosage of thyroid hormone suppression and/or...

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