Long-term depression
Автор:
Jesse Russell,Ronald Cohn, 105 стр., издатель:
"Книга по Требованию", ISBN:
978-5-5093-0045-5
High Quality Content by WIKIPEDIA articles! Long-term depression (LTD), in neurophysiology, is an activity-dependent reduction in the efficacy of neuronal synapses lasting hours or longer following a long patterned stimulus. LTD occurs in many areas of the CNS with varying mechanisms depending upon brain region and developmental progress. LTD in the hippocampus and cerebellum have been the best characterized, but there are other brain areas in which mechanisms of LTD are understood. LTD has also been found to occur in different types of neurons that release various neurotransmitters, however, the most common neurotransmitter involved in LTD is L-glutamate. L-glutamate acts on the N-methyl-D- asparate receptors (NMDARs), ?-amino-3-hydroxy-5-methylisoxazole-4-propionicacid receptors (AMPARs), kinate receptors (KARs) and metabotropic glutamate receptors (mGluRs) during LTD. It can result from strong synaptic stimulation (as occurs in the cerebellar Purkinje cells) or from persistent weak...
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