High Quality Content by WIKIPEDIA articles! Serotonin–norepinephrine reuptake inhibitors (SNRIs) are a class of antidepressant drugs used in the treatment of major depressive disorder (MDD). SNRIs are potent inhibitors of serotonin (5-Hydroxytryptamine, 5-HT) and norepinephrine (NE, noradrenalin) reuptake. These neurotransmitters are known to play an important role in mood. The human serotonin transporter (SERT) and norepinephrine transporter (NET) are membrane proteins that are responsible for the reuptake of serotonin and norepinephrine. Balanced dual inhibition of monoamine reuptake can possibly offer advantages over other antidepressants drugs by treating a wider range of symptoms. SNRIs are second-generation agents, such as selective serotonin reuptake inhibitors (SSRIs) and norepinephrine reuptake inhibitors (NRIs). Over the past two decades, second-generation agents have gradually replaced first-generation agents, such as tricyclic antidepressants (TCAs) and monoamine oxidase...

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