Recombinant AAV mediated genome engineering
Автор:
Jesse Russell,Ronald Cohn, 101 стр., издатель:
"Книга по Требованию", ISBN:
978-5-5087-6272-8
High Quality Content by WIKIPEDIA articles! Recombinant adeno-associated virus (rAAV) based genome engineering is a genome editing platform centered around the use of rAAV vectors that enables insertion, deletion or substitiution of DNA sequences into the genomes of live mammalian cells. The technique builds on Capecchi and Smithies’ Nobel Prize winning discovery that homologous recombination (HR), a natural DNA repair mechanism, can be harnessed to perform precise genome alterations in mice. rAAV mediated genome improves the efficiency of this technique to permit genome engineering in any pre-established and differentiated human cell line, which in contrast to mouse ES cells, have low rates of HR. Данное издание представляет собой компиляцию сведений, находящихся в свободном доступе в среде Интернет в целом, и в информационном сетевом ресурсе "Википедия" в частности. Собранная по частотным запросам указанной тематики, данная компиляция построена по принципу подбора близких...