Transneuronal degeneration
Автор:
Jesse Russell,Ronald Cohn, 105 стр., издатель:
"Книга по Требованию", ISBN:
978-5-5087-0176-5
High Quality Content by WIKIPEDIA articles! Transneuronal degeneration is the death of neurons resulting from the disruption of input from or output to other nearby neurons. It is an active excitotoxic process when a neuron is overstimulated by a neurotransmitter (most commonly glutamate) causing the dysfunction of that neuron (either damaging it or killing it) which drives neighboring neurons into metabolic deficit, resulting in rapid, widespread loss of neurons. This can be either anterograde or retrograde, indicating the direction of the degeneration relative to the original site of damage (see types). There are varying causes for transneuronal degeneration such as brain lesions, disconnection syndromes, respiratory chain deficient neuron interaction, and lobectomies. Although there are different causes, transneuronal degeneration generally results in the same effects (whether the be cellular, dendritic, or axonal) to varying degrees. Transneuronal degeneration is thought to be...
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