High Quality Content by WIKIPEDIA articles! Osteitis fibrosa cystica ( /??sti??a?t?s fa??bro?s? ?s?st?k?/), abbreviated OFC, and also known as osteitis fibrosa, osteodystrophia fibrosa, not to be confused with Von Recklinghausen's disease of bone (]). Osteitis Fbrosa Cystica is a skeletal disorder caused by a surplus of parathyroid hormone from over-active parathyroid glands. This surplus stimulates the activity of osteoclasts, cells that break down bone, in a process known as osteoclastic bone resorption. The over-activity of the parathyroid glands, or hyperparathyroidism, can be triggered by parathyroid adenoma, hereditary factors, parathyroid carcinoma, or renal osteodystrophy. Osteoclastic bone resorption releases minerals, including calcium, from the bone into the bloodstream. In addition to elevated blood calcium levels, over-activity of this process results in a loss of bone mass, a weakening of the bones as their calcified supporting structures are replaced with fibrous tissue...

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