The year is 1688 and it is a clear Spring day in Paris. At the court of Chastelet a distinguished and learned crowd is gathered to view the trial of Jean–Baptise Denis a bright young mathematician with an interest in medicine. Denis has recently earned himself a place in history by being the first person to perform a blood transfusion on a human being. But things have not gone well for Denis or for Antoine Mauroy, his patient. Mauroy has died and Denis is on trial for murder. This fascinating tale of madness, corruption and intrigue roams from Classical Greece to the London of Sir Christopher Wren and the Paris of Louis XIV. The exploration of profound ethical dilemmas is as relevant today as in Denis? own time.

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