While much research has attempted to show direct linear relations between genes and disorder, scientists have been discouraged by inconsistent findings based on this simple gene–phenotype approach. An alternative approach is to incorporate information about the environment. The gene–environment interaction approach focuses on the circumstances in which there is an environmental determinant of disease but where genes influence susceptibility to that environmental factor. Genetic Effects on Environmental Vulnerability to Disease is based on the final meeting of the Novartis Foundation Symposium Series (#293 Understanding How Gene Environment Interactions Work to Predict Disorder). Contributions from geneticists, physicians, oncologists, biologists, statisticians, epidemiologists, psychiatrists and psychologists address: · how physiological (mechanistic) measures can be better integrated into epidemiological cohort studies · how best to characterise...

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