This fourth edition of Peter Gotzsche’s ‘Rational Diagnosis and Treatment’ argues that clinical decision–making should be built from first principles. By asking relevant questions, such as ‘how reliable are various sorts of data?’, ‘how has the disease classification evolved over time, and is it logical?’, fewer mistakes will be made by the practising physician and trainee. This beautifully written book integrates the science and statistical approach of evidence–based medicine with the art and humanism of medical practice. It stresses that, whenever possible, clinical decisions must be based on the best evidence from clinical research; but also highlights the pitfalls of such research and the problems involved in applying evidence from groups of patients to the individual patient. Such an intellectually challenging book is ideal for medical students, practitioners and doctors who require theoretical and practical clinical skills to help ensure that they apply theory to...

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