A how–to guide that helps you take advantage of the latest mass spectrometry methods This book brings together and examines the latest mass spectrometry methods used to investigate proteins, including structural mechanisms, protein dynamics, and interactions among proteins. Written by a team of experts with many years of hands–on experience developing and working with mass spectrometry methods, the book offers a wealth of practical advice and tips to help readers fully exploit the capabilities of a mass spectrometer. The book begins with an overview of mass spectrometry technologies, including an expert forecast of future directions. Next, the authors offer step–by–step guidance for such topics as: Complementary methods for structure determination: hydroxyl radical–mediated footprinting and deuterium exchange mass spectrometry as applied to serpin structure Covalent labeling methods for examining protein structure and protein interactions ...

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